Language learning difficulties in children linked to brain differences

A new study using MRI has revealed structural brain changes in children with developmental language disorder (DLD), a common but under-recognised difficulty in language learning. Children with DLD aged 10-15 showed reduced levels of myelin in areas of the brain associated with speaking and listening to others, and areas involved in learning new skills. This finding is a significant advance in our understanding of DLD and these brain differences may explain the poorer language outcomes in this group.

DLD is an extremely common disorder, affecting approximately two children in every classroom. Children with DLD struggle to comprehend and use their native language, facing trouble with grammar, vocabulary, and holding conversations. Their language difficulties considerably increase the risk of having difficulties when learning to read, underachieving academically, being unemployed, and facing social and mental health challenges.

In this research, published in the journal eLife, Dr Saloni Krishnan and colleagues used MRI brain scans that were specifically sensitive to different properties of the brain tissue. For example, the scans measured the amount of myelin and iron in the brain. Myelin is a fatty substance that wraps around neurons and speeds up transmission of signals between brain areas. It is like the insulation around electrical cables. The research demonstrated that children with DLD have less myelin in parts of the brain responsible for acquiring rules and habits, as well as those responsible for language production and comprehension.

Dr Krishnan (Reader, Royal Holloway, University of London), who led the study as a Research Fellow at the University of Oxford, said: ‘DLD is a relatively unknown and understudied condition, unlike better known neurodevelopmental conditions such as ADHD, dyslexia, or autism. This work is an important first step in understanding the brain mechanisms of this disorder.’

Senior author Kate Watkins, Professor of Cognitive Neuroscience at the University of Oxford, said: ‘This type of scan tells us more about the make up or composition of the brain tissue in different areas. The findings might help us understand the pathways involved at a biological level and ultimately allow us to explain why children with DLD have problems with language learning.’
More studies are needed to determine if these brain differences cause language problems and how or if experiencing language difficulties could cause these changes in the brain. Further research may help scientists find new treatments that target these brain differences.

The University of Oxford’s Experimental Psychology Department’s mission is to conduct world-leading experimental research to understand the psychological and neural mechanisms relevant to human behaviour. Wherever appropriate, we translate our findings into evidence-based public benefits in mental health and well-being, education, industry, and policy. Key areas of research include Behavioural Neuroscience, Developmental Psychology, Social Psychology, and Psychological and Brain Health.

The University of Oxford

Oxford University has been placed number 1 in the Times Higher Education World University Rankings for the sixth year running, and 2 in the QS World Rankings 2022. At the heart of this success is our ground-breaking research and innovation.
Oxford is world-famous for research excellence and home to some of the most talented people from across the globe. Our work helps the lives of millions, solving real-world problems through a huge network of partnerships and collaborations. The breadth and interdisciplinary nature of our research sparks imaginative and inventive insights and solutions.
Through its research commercialisation arm, Oxford University Innovation, Oxford is the highest university patent filer in the UK and is ranked first in the UK for university spinouts, having created more than 200 new companies since 1988. Over a third of these companies have been created in the past three years. The university is a catalyst for prosperity in Oxfordshire and the United Kingdom, contributing £15.7 billion to the UK economy in 2018/19, and supports more than 28,000 full time jobs.

Source – Oxford